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金配合物是以金离子为中心所形成的一类配合物,其中金离子具有特殊的电子结构,故在氧化还原反应中非常活跃,可使配合物与细胞内还原性生物大分子发生相互作用,进而发挥药理活性。近来,研究人员通过对与金离子配位结合的配体进行替换或修饰,设计并合成了一系列性质稳定、功能多样化的金配合物。对几种抗肿瘤活性显著的+1和+3价金配合物及其研究进展进行综述。
Gold complexes are gold ions as the center of the formation of a class of complexes, of which gold has a special electronic structure, it is very active in the redox reaction, the complex with the intracellular reductive biomacromolecules can interact , And then play a pharmacological activity. Recently, researchers have designed and synthesized a series of stable and versatile gold complexes by replacing or modifying ligands that coordinate with gold ions. Several anti-tumor activity significant +1 and +3 gold complexes and its research progress are reviewed.