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目的 观察癫痫大鼠脑中的一氧化氮 (NO)和超氧化物歧化酶 (SOD)的变化 ,并探讨 NO的氧化还原状态对癫痫的作用。方法 通过美解眠诱发致痫的大鼠模型 ,分别取癫痫发作时及癫痫发作刚停止时的大脑运动区皮质 ,匀浆后测定 NO的含量和 SOD活力。结果 癫痫发作组及癫痫发作刚停止组 ,大脑运动皮质的 NO含量均较正常对照组明显升高 ;癫痫发作组 ,脑内 SOD活力反而下降 ,癫痫发作刚停止组 ,脑内SOD活力明显升高。结论 癫痫发作组和短暂发作刚停止组 ,SOD活力 / NO含量比值具有显著差异 ,这些结果支持 NO的不同氧化还原状态在癫痫发作中起到不同的作用。
Objective To observe the changes of nitric oxide (NO) and superoxide dismutase (SOD) in the brain of epileptic rats and to explore the effect of NO on the epilepsy. Methods The rat model of epilepsy induced by US hypnosis was established. The cortical regions of the motor area of the brain during epileptic seizures and just after the seizures were stopped. The content of NO and the activity of SOD were determined after homogenization. Results In seizure group and epileptic seizure group, the content of NO in cerebral cortex was significantly higher than that in normal control group. In seizure group, the activity of SOD in the brain decreased but the activity of SOD in the brain was increased . Conclusions There is a significant difference in the ratio of SOD activity / NO content between epileptic seizures and those with just ephemeral seizures. These results support that different redox states of NO play different roles in seizures.