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目的探讨莫沙必利联合奥美拉唑治疗胃食管反流病的临床疗效和安全性。方法2010年1月～2012年12月我院收治的128例胃食管反流病患者，进行随机分组，其中64例作为研究组（M组），M组患者给予枸橼酸莫沙必利联合奥美拉唑治疗，对照组64例（D组）患者仅单纯给予奥美拉唑治疗，两组疗程均为8周，比较分析两组患者的临床疗效与不良反应。结果观察组患者治疗总有效率达到92.27％，观察组患者治疗总有效率达到8O.48％，两组患者在治疗有效率比较上差异具有统计学意义( P 0.05), UPDRS scores were significantly decreased after treatment of the P group of patients, the difference was statistical y significant (P 0.05). After 12 weeks of treatment, the study group, 72 cases (80.00%) markedly effective in 45 cases, the control group (46.88%), the difference was statistical y significant (P 0.05). Conclusion:The application of L-dopa treatment of Parkinson’s patients on the basis of adding pramipexole treatment Can effectively al eviate the symptoms of the disease,improve patient quality of life, Should be widely applied.