已知人的心房内存在着具有很强利尿作用的肽,其全部氨基酸排列顺序也已明确。这种肽不仅仅作用于肾脏,影响水、电解质代谢,而且也作用于血管平滑肌,使之松弛。这是一种正在被人们注目的参与全身循环系统调节的新体液性因子。以往,关于这种肽类物质人们进行了种种有关生物活性的研究,一致认为它可使尿量增加,肾血管扩张,也影响肾小球滤过率。这些实验多是用心房的粗提取物进行的,因此它对肾功能的影响还不能从定量的角度给以详细的评价。 把由28个氨基酸组成的人心房性钠利尿肽(a—hANP)给已麻醉的狗由肾动脉注入,小量使用可看到肾血流量、肾小球滤过率没有变化。但尿量、尿中电解质排泄量增加。如增加用量、肾血流量和肾小球滤过率增加,并伴有利尿作用进一步增强。从自 It is known that there is a peptide having a strong diuretic effect in the human atrium, and the order of all the amino acids has also been clarified. This peptide acts not only on the kidneys, affecting water and electrolyte metabolism, but also acting on the smooth muscles of the blood vessels to relax them. This is a new humoral factor that is attracting attention in the regulation of the systemic circulation. In the past, people on this peptide material carried out a variety of biological activity, agreed that it can increase urine output, renal vasodilation, but also affect the glomerular filtration rate. These experiments are mostly carried out with atrial crude extract, so its impact on renal function can not be given a detailed assessment from a quantitative point of view. Human atrial natriuretic peptide (a-hANP), consisting of 28 amino acids, was injected into the anesthetized dogs through the renal artery. When used in small quantities, the renal blood flow was observed and there was no change in glomerular filtration rate. However, urine output, urinary electrolyte excretion increased. Such as increasing the amount of renal blood flow and glomerular filtration rate increased, accompanied by further diuretic effect. From