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目的观察小剂量布地奈德联合茶碱缓释片干预性治疗婴幼儿喘息发作的疗效。方法将90例毛细支气管炎患儿随机分为观察组和对照组各45例。对照组予布地奈德雾化吸入等常规治疗,观察组患者在常规治疗基础上加用小剂量布地奈德联合茶碱缓释片治疗(疗程12周)。比较2组患儿临床疗效及随访1年喘息发作情况。结果观察组患儿咳嗽、喘息及哮鸣音等临床症状体征消退时间和住院时间均短于对照组(P<0.05);随访1年,观察组患儿喘息发作次数及喘息症状评分均明显低于对照组(P<0.05)。结论小剂量布地奈德联合茶碱缓释片干预性治疗可有效预防婴幼儿喘息发作。
Objective To observe the effect of low-dose budesonide combined with theophylline sustained-release tablets in the treatment of infantile wheezing. Methods Ninety children with bronchiolitis were randomly divided into observation group and control group, 45 cases each. The control group was given Budesonide inhalation and other conventional treatment. The patients in the observation group were treated with low-dose budesonide combined with theophylline sustained-release tablets (for 12 weeks) on the basis of routine treatment. The clinical efficacy of two groups were compared and the wheezing episodes were followed up for one year. Results The cough, wheezing and wheeze in observation group were shorter than those in control group (P <0.05). The number of wheezing and wheezing in observation group was significantly lower than that in control group In the control group (P <0.05). Conclusion The intervention of low-dose budesonide combined with theophylline sustained-release tablets can effectively prevent wheezing in infants and young children.