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目的比较两种方法治疗小儿手足口病的临床疗效。方法选择2008年6-10月我院收治的小儿手足口病一般病例126例,随机分为观察组和对照组,每组62例。两组患儿均给予相同的对症及支持治疗,酌情使用抗生素。对照组应用病毒唑葡萄糖注射液静滴,治疗组应用莪术油注射液联合病毒唑葡萄糖注射液静滴。观察记录两组患儿退热时间、皮疹消退时间、住院时间及毒副作用发生情况,疗效结束后对两组患儿的疗效进行评估。结果观察组在退热时间、皮疹消退时间、口腔愈合时间和住院时间均比对照组明显缩短,经统计学处理差异有统计学意义(P<0.01),两组患儿总有效率比较差异有统计学意义(χ2=6.72,P<0.05),提示治疗组疗效明显优于对照组。治疗过程中两组均未见明显毒副作用发生,均无并发症发生。结论莪术油注射液联合病毒唑治疗小儿手足口病具有显著临床疗效,优于单用病毒唑治疗。
Objective To compare the clinical efficacy of two methods in treating children’s hand, foot and mouth disease. Methods 126 cases of HFMD in children admitted to our hospital from June to October in 2008 were randomly divided into observation group and control group, with 62 cases in each group. Two groups of children were given the same symptomatic and supportive treatment, as appropriate, the use of antibiotics. The control group was treated with intravenous injection of ribavirin and dextrose injection. The treatment group was treated with Curcuma oil injection combined with intravenous injection of ribavirin and glucose injection. Observed and recorded two groups of children with antipyretic time, rash subsided time, hospitalization time and the occurrence of toxic and side effects, the efficacy of the efficacy of the two groups after the assessment. Results The observation group was significantly shorter in the antipyretic time, rash subsidence time, oral healing time and hospitalization time than the control group, and the difference was statistically significant (P <0.01). The total effective rate in the two groups was Statistical significance (χ2 = 6.72, P <0.05), suggesting that the treatment group was significantly better than the control group. No significant side effects occurred in both groups during the treatment, and no complication occurred. Conclusion Curcuma oil injection combined with ribavirin in the treatment of children with hand-foot-mouth disease has a significant clinical effect, superior to ribavirin alone.