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目的探讨丹参川芎嗪注射液对高血压脑出血患者的影响。方法选取2013年2月—2016年5月内蒙古医科大学附属医院收治的高血压脑出血患者118例,采用抽签法分为对照组和观察组,每组59例。对照组患者给予西医常规治疗,观察组患者在西医常规治疗基础上给予丹参川芎嗪注射液,连续治疗28 d。比较两组患者治疗前后格拉斯哥昏迷量表(GCS)评分、神经功能缺损评分、血清肿瘤坏死因子α(TNF-α)及白介素6(IL-6)水平、脑水肿程度、预后。结果两组患者治疗前GCS评分、神经功能缺损评分比较,差异无统计学意义(P>0.05);观察组患者治疗后GCS评分高于对照组,神经功能缺损评分低于对照组(P<0.05)。两组患者治疗前血清TNF-α、IL-6水平比较,差异无统计学意义(P>0.05);观察组患者治疗后血清TNF-α、IL-6水平低于对照组(P<0.05)。两组患者治疗前脑水肿程度比较,差异无统计学意义(P>0.05);观察组患者治疗后脑水肿程度轻于对照组(P<0.05)。观察组患者预后良好率高于对照组(P<0.05)。结论在西医常规治疗基础上加用丹参川芎嗪注射液有利于减轻高血压脑出血患者脑水肿,促进患者神经功能恢复,改善患者预后。
Objective To investigate the effect of ligustrazine injection on patients with hypertensive intracerebral hemorrhage. Methods 118 patients with hypertensive intracerebral hemorrhage admitted to the Affiliated Hospital of Inner Mongolia Medical University from February 2013 to May 2016 were randomly divided into control group and observation group with 59 cases in each group. Patients in the control group were given conventional western medicine. Patients in the observation group were given Salviae Miltiorrhizae ligustrazine injection on the basis of routine treatment of Western medicine for continuous treatment for 28 days. Glasgow coma scale (GCS) score, neurological deficit score, serum tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) levels, brain edema and prognosis were compared between the two groups before and after treatment. Results There was no significant difference in GCS score and neurological deficit score between the two groups before treatment (P> 0.05). GCS score of the observation group was higher than that of the control group, and neurological deficit score was lower than that of the control group (P <0.05) ). The serum levels of TNF-α and IL-6 in the two groups before treatment were not significantly different (P> 0.05). The levels of TNF-α and IL-6 in the observation group were lower than those in the control group (P <0.05) . There was no significant difference between the two groups in the treatment of forebrain edema (P> 0.05). The degree of brain edema in the observation group was lighter than that of the control group (P <0.05). The good prognosis of the observation group was higher than that of the control group (P <0.05). Conclusion Adding traditional Chinese medicine treatment of Ligustrazine on the basis of conventional treatment is beneficial to relieve brain edema in patients with hypertensive intracerebral hemorrhage and promote the recovery of neurological function and prognosis of patients.