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作者应用表阿霉素对进展期胃癌作早期腹腔内化疗,并对EPIC的可行性及临床意义进行探讨.本组18例进展期胃癌中,腺癌8例,印戒细胞癌5例,未分化癌5例;根据国际新TNM分期,Ⅲa2例,Ⅲb4例,Ⅳ12例;手术方式:行R31例,R26例,R13例;姑息性全胃切除2例,姑息性胃大部切除6例;消化道重建:食道一空肠Roux-Y吻合术2例,BillrothⅠ式11例,Billroth Ⅱ2例;18例共有吻合口27个,均为单层连续或间断吻合.EPIC方法:关腹前手术野彻底止血,于胃床部位置直径3mm硅胶管,自切口上端引流管注入含表阿霉素10mg/L的Ringer液1000ml,15～30min注完,然后嘱病人反复变动体位,使药液分布均匀;次日注药前开放
The authors used epirubicin to perform early intraperitoneal chemotherapy for advanced gastric cancer, and to explore the feasibility and clinical significance of EPIC. In this group of 18 cases of advanced gastric cancer, adenocarcinoma in 8 cases, signet ring cell carcinoma in 5 cases, not According to the international new TNM staging, IIIa2 cases, IIIb4 cases, IV12 cases; surgical methods: R31 cases, R26 cases, R13 cases; palliative total gastrectomy in 2 cases, palliative gastrectomy in 6 cases; Gastrointestinal reconstruction: Roux-Y anastomosis of the esophagus and jejunum occurred in 2 cases, Billroth I type in 11 cases, and Billroth II in 2 cases; 18 cases had a total of 27 anastomotic sites, all of which were single-layer continuous or intermittent anastomosis. EPIC method: pre-abdominal surgical field thorough Stop the bleeding, place a 3mm diameter silicone tube on the stomach bed, and inject 1000ml of Ringer’s solution containing 10mg/L of epirubicin into the drainage tube at the upper end of the incision, and then inject it for 15-30min. Then, repeat the position of the patient to make the liquid evenly distributed. Open before the next injection