近年的研究发现 ,离子通道功能异常与多种疾病尤其是神经系统疾病密切相关[1,2 ] 。它既可由编码离子通道的基因发生先天性突变导致 ,也可由体内出现针对离子通道的抗体引起 ,广义上都可归为离子通道病 (channelopathy) ,其中后者多为自身免疫介导 ,可累及中枢、外周神经系统及 In recent years, studies have found that ion channel dysfunction and a variety of diseases, especially nervous system diseases are closely related [1,2]. It can be caused by congenital mutations in genes encoding ion channels, antibodies in ion channels in vivo, and broadly classified as channelopathy, the latter mostly mediated by autoimmunity and can be involved Central, peripheral nervous system and