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糖尿病(DM)及其并发症的发生发展与多种因素有关,除通常所说的遗传和生活方式等因素外,还与众多细胞因子和酶活性改变有关。2型糖尿病(2TDM)广泛的代谢异常可引起基底膜的结构和功能发生改变,这些改变可使血管基底膜的降解与重构机制失常,而细胞外基质(ex trace llu lar m atri
The occurrence and development of diabetes mellitus (DM) and its complication are related to a variety of factors, including the genetics and lifestyle, as well as the changes of many cytokines and enzymes. Extensive metabolic abnormalities in type 2 diabetes mellitus (2TDM) can cause changes in the structure and function of the basement membrane, which can lead to aberrant mechanisms of degradation and remodeling of the vascular basement membrane, whereas extrinsic luteum