论文部分内容阅读
后囊混浊是白内障囊外摘出术的首要并发症。晶体上皮细胞的增殖、移行和纤维化在后囊混浊的发生中起了重要作用。目前,后囊混浊的预防以手术中彻底清除晶体上皮细胞及皮质、植入双凸或后凸的后房型人工晶体为主。其治疗主要靠激光后囊膜切开。研究发现,Dispase(一种中性蛋白酶)、依地酸(EDTA)、肝素及抗代谢药5-氟尿嘧啶、柔红霉素、秋水仙碱、丝裂霉素等对晶体上皮细胞的移行和/或增殖有抑制作用。多种细胞因子对晶体上皮细胞的增殖或抑制作用也引人注目
Posterior capsule opacification is the primary complication of extracapsular cataract extraction. Proliferation, migration and fibrosis of the lens epithelial cells play an important role in the occurrence of posterior capsular opacities. At present, the prevention of posterior capsular opacification by surgery to completely remove the crystalline epithelial cells and cortex, implanted lenticular or kyphosis posterior chamber intraocular lens based. The treatment mainly depends on the laser posterior capsule incision. The study found that Dispase (a neutral protease), edetic acid (EDTA), heparin and anti-metabolites 5-fluorouracil, daunorubicin, colchicine, mitomycin and other crystal epithelial cell migration and / Or proliferation inhibition. A variety of cytokines on the proliferation of epithelial cells or inhibitory effect is also remarkable