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目的探讨表皮生长因子受体(EGFR)、血管内皮生长因子受体-3(VEGFR-3)和血小板源性生长因子受体(PDGFR)的表达与非小细胞肺癌(NSCLC)生物学行为的关系及其内在联系。方法用免疫组化SP法对205例Ⅰ~Ⅲ期NSCLC根治手术后的标本进行EGFR、VEGFR-3、PDGFR表达检测。结果 EGFR、VEGFR-3、PDGFR的阳性表达率分别为36.1%、90.2%、61.5%。EGFR的表达与淋巴结转移个数有关;VEGFR-3表达与N分期、胸膜侵犯有关。PDGFR的表达评分与VEGFR-3的表达评分呈正相关,r=0.255,P=0.001。结论 EGFR、VEGFR-3是NSCLC淋巴转移与局部侵犯的相关因素,PDGFR与VEGFR-3可能存在某种内在联系,对多靶点靶向药物的研发及靶向治疗药物的联合应用具有提示意义。
Objective To investigate the relationship between the expression of epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor-3 (VEGFR-3) and platelet-derived growth factor receptor (PDGFR) and the biological behavior of non-small cell lung cancer And its internal relations. Methods The expressions of EGFR, VEGFR-3 and PDGFR in 205 patients with stage Ⅰ-Ⅲ NSCLC after radical operation were detected by immunohistochemical SP method. Results The positive rates of EGFR, VEGFR-3 and PDGFR were 36.1%, 90.2% and 61.5% respectively. The expression of EGFR is related to the number of lymph node metastasis. The expression of VEGFR-3 is related to N stage and pleural invasion. The expression of PDGFR was positively correlated with the expression of VEGFR-3, r = 0.255, P = 0.001. Conclusions EGFR and VEGFR-3 are the related factors of lymphatic metastasis and local invasion in NSCLC. PDGFR and VEGFR-3 may have some intrinsic relationship, which is of great significance to the development of multi-target drug and the combination of targeted therapy.