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本课题通过硝酸盐还原酶法测定血清NO含量,探讨高血压病、脑梗塞患者发病及治疗前后血清NO含量变化。对入选95例脑梗塞患者、96例高血压病患者及100例健康献血者,测定血清NO含量。结果:高血压病、脑梗塞患者血清NO含量明显低于正常对照组,经心痛定及脉络宁治疗后,血清NO含量水平较治疗对照组呈显著性差异(P<0.01),为临床药物治疗提供了一定的理论依据。
The subject of nitrate reductase determination of serum NO content, explore the pathogenesis of hypertension, cerebral infarction and serum NO levels before and after treatment. Serum NO levels were measured in 95 patients with cerebral infarction, 96 patients with hypertension and 100 healthy blood donors. Results: Serum NO levels in patients with hypertension and cerebral infarction were significantly lower than those in the normal control group. The levels of NO in serum were significantly different from those in the control group (P <0.01) after treatment with xintongding and Mailuoning. Provided a certain theoretical basis.