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目的:探讨大鼠心肌梗死后应用瑞舒伐他汀对左室重构和心功能的影响。方法:30只健康成年雄性SD大鼠随机分为正常组、心梗组和瑞舒伐他汀治疗组(瑞舒伐他汀10mg/kg加入2ml蒸馏水每天灌胃1次,持续6周)。治疗前后分别检测3组大鼠的左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、舒张末期左室后壁厚度(LVPWD)、左室射血分数(LVEF)和短轴缩短率(LVFS);6周后测定左室血流动力学指标,包括左室收缩压(LVSP)和左室舒张末压(LVEDP);大鼠处死后,测量左心室重量及左心重量指数。结果:治疗6周后,与正常组相比,心梗阻和治疗组的左心室重量及左心室重量指数均显著增加,动脉压各指标(SBP、DBP、MBP)和LVSP均显著降低,LVEDP则显著升高。但与心梗组比较,治疗组的左心室重量及左心室重量指数均显著降低,SBP、DBP、MBP和LVSP均显著提高,LVEDD、LVESD与LVPWD均明显降低,LVEF与LVFS则显著升高。结论:大鼠心肌梗死后应用瑞舒伐他汀可以明显改善左室重构和左室功能。
Objective: To investigate the effect of rosuvastatin on left ventricular remodeling and cardiac function after myocardial infarction in rats. Methods: Thirty healthy adult male Sprague-Dawley rats were randomly divided into normal group, myocardial infarction group and rosuvastatin treatment group (Rosuvastatin 10mg / kg, adding 2ml of distilled water once daily for 6 weeks). Before and after treatment, left ventricular end-diastolic dimension (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular posterior wall thickness (LVPWD), left ventricular ejection fraction (LVEF) (LVFS). Left ventricular hemodynamic parameters including left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP) were measured after 6 weeks. Left ventricular mass and left ventricular mass index were measured after sacrificed. Results: Compared with the normal group, the left ventricular mass and left ventricular mass index increased significantly after 6 weeks of treatment, and the indexes of arterial pressure (SBP, DBP, MBP) and LVSP were significantly lower than those of the normal group Significantly increased. Compared with the myocardial infarction group, the left ventricular mass and left ventricular mass index of the treatment group were significantly decreased, the SBP, DBP, MBP and LVSP were significantly increased, LVEDD, LVESD and LVPWD were significantly decreased, LVEF and LVFS were significantly increased. Conclusion: The application of rosuvastatin can significantly improve left ventricular remodeling and left ventricular function after myocardial infarction in rats.