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本文检测24例狼疮肾炎(LN)患者、7例无临床肾损害表现的SLE患者及11例正常人尿血栓素B_2(TXB_2)、6-酮-前列腺素F_1α(6-Keto-PGF_1α)排泄水平。结果示LN病人尿TXB_2/6-Keto-PGF_1α(T/K)值较无临床肾损害SLE患者及正常人均增高,差异显著,且T/K值与肾有效血浆流量(REPF)呈显著性负相关;与24小时尿蛋白呈显著性正相关。尿T/K值可作为临床上判断LN患者病情和估计预后的指标之一。
Twenty-four patients with lupus nephritis (LN), 7 patients with SLE without clinical renal impairment, and 11 normal subjects were tested for urinary TXB 2 and 6-Keto-PGF 1α excretion . The results showed that the urinary TXB_2 / 6-Keto-PGF_1α (T / K) value of LN patients was significantly higher than that of patients without SLE and normal persons, and the T / K value was significantly negative with the renal effective plasma flow (REPF) Related; and 24-hour urine protein was significantly positive correlation. Urine T / K value can be used as clinical judgment LN disease and prognosis of one of the indicators.