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用高效液相色谱法测定大鼠ig（灌胃）和阴道给药米非司酮（均为16mg／kg）后0.5、1、2、4、8、24、48h的血清浓度，根据各鼠血药浓度-时间数据拟会曲线，ig呈二室动力学模型，阴道给药呈一空动力学模型，其Tmax分别为2.43h、4.50h；Cmax分别为320．60μg／ml、129．64μg／ml；Ka分别为0．84／h、0．67／h；T1／2分别为（1）0．88h、0．98h；（2）1．65h、15．07h；Auc分别为5153．1μg·h／ml，3155．99μg·h／ml；K10分别为0．12／h，1．06／h。结果显示米非司酮ig血药浓度较阴道给药血药浓度为高。
The serum concentrations of ig (gavage) and vaginal administration of mifepristone (both 16 mg / kg) at 0.5, 1, 2, 4, 8, 24 and 48 h were determined by high performance liquid chromatography The plasma concentration-time data fitting curve, ig showed a two-compartment kinetic model, vaginal administration was an empty kinetic model, the Tmax were 2.43h, 4.50h; Cmax were 320.60μg / ml, 129.64μg / ml; Ka were 0.84 / h, 0.67 / h; T1 / 2 were (1) 0.88h, 0.98h; (2) 1.65h, 15.07h; Auc were 5153.1μg · H / ml, 3155.99 μg · h / ml; K10 respectively 0.12 / h, 1.06 / h. The results showed that plasma concentrations of mifepristone ig higher than the vaginal drug concentration.