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目的观察冠心病患者血清尿酸、C-反应蛋白含量变化及其临床意义。方法选择35例冠心病心绞痛患者及30例健康者(对照组),用尿酸酶法测尿酸含量、用比浊法测量C-反应蛋白含量。结果冠心病心绞痛组与对照组血尿酸比较:冠心病心绞痛组(382±99)μmol/L,对照组(337±87)μmol/L,(P<0.01)。心病心绞痛组与对照组C-反应蛋白比较:冠心病心绞痛组(2.7±0.3)mg/L,对照组(1.9±0.2)mg/L,(P<0.05)。结论血清尿酸、C-反应蛋白在冠心病心绞痛的发生、发展中起重要作用,对临床升高的尿酸及C-反应蛋白应进行及早干预和有效治疗,以防不良心血管事件的发生。
Objective To observe the changes of serum uric acid and C-reactive protein in patients with coronary heart disease and its clinical significance. Methods Thirty-five patients with angina pectoris and 30 healthy controls (control group) were enrolled in this study. Uricase was used to measure uric acid and turbidimetric method to measure C-reactive protein. Results Serum uric acid in coronary heart disease group was higher than that in control group (382 ± 99) μmol / L in coronary heart disease group and (337 ± 87) μmol / L in control group (P <0.01). The levels of C-reactive protein in patients with angina pectoris group and control group were significantly higher than those in patients with coronary heart disease angina pectoris (2.7 ± 0.3) mg / L and those in control group (1.9 ± 0.2) mg / L, respectively (P <0.05). Conclusions Serum uric acid and C-reactive protein play an important role in the occurrence and development of angina pectoris. Clinically elevated uric acid and C-reactive protein should be treated as soon as possible and effectively treated to prevent the occurrence of adverse cardiovascular events.