论文部分内容阅读
目的探讨术前外周血单核细胞计数与结直肠癌肝转移的关系。方法收集2003年12月至2015年5月住院手术治疗的结直肠癌患者195例的临床资料,根据患者术前是否有肝转移灶分为肝转移组30例和无肝转移组16例。对患者临床病理特征进行单因素分析,对结直肠癌肝转移危险因素进行多因素Logistic回归分析,以确定单核细胞计数是否与结直肠癌肝转移有关联。结果 103例结肠癌中26例发生肝转移,92例直肠癌中4例发生肝转移。单因素分析显示,肝转移组和无肝转移组患者的性别、年龄、原发肿瘤最大直径、分化程度差异均无统计学意义(P均>0.05);两组患者在术前单核细胞计数、T分期、N分期、肿瘤原发部位差异有统计学意义(P均<0.01)。结直肠癌肝转移危险因素的Logistic回归分析显示,术前高单核细胞计数是结直肠癌患者发生肝转移的独立危险因素(OR:8.172,95%CI:3.685~18.119,P<0.01)。结论升高的术前外周血单核细胞计数与结直肠癌肝转移相关,可能通过导致肿瘤患者处于免疫抑制状态促进了结直肠癌肝转移。
Objective To investigate the relationship between preoperative peripheral blood mononuclear cell count and hepatic metastasis of colorectal cancer. Methods The clinical data of 195 patients with colorectal cancer hospitalized from December 2003 to May 2015 were collected and divided into liver metastasis group (n = 30) and non-liver metastasis group (n = 16) according to whether there was liver metastasis before surgery. Univariate analysis of clinical pathological features of patients with colorectal cancer risk factors for liver metastasis by multivariate Logistic regression analysis to determine whether the monocyte count associated with liver metastases of colorectal cancer. Results Of the 103 cases of colon cancer, 26 cases of liver metastases, 92 cases of rectal cancer in 4 cases of liver metastases. Univariate analysis showed that there was no significant difference in gender, age, maximum diameter of primary tumor and differentiation between patients with and without liver metastasis (all P> 0.05). The preoperative mononuclear cell count , T stage, N stage, tumor primary site difference was statistically significant (P all <0.01). Logistic regression analysis showed that preoperative monocyte count was an independent risk factor for liver metastasis in patients with colorectal cancer (OR: 8.172, 95% CI: 3.685-18.119, P <0.01). Conclusions Increased preoperative peripheral blood mononuclear cell count is associated with liver metastasis of colorectal cancer and may promote hepatic metastasis of colorectal cancer by causing the tumor patients to be immunosuppressed.