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目的 了解高血压家系和非高血压家系后代中 ,胰岛素受体底物 1(IRS 1)基因多态性与血糖水平的关系。 方法 对大庆地区 184个高血压家系和 99个非高血压家系的第一代直系亲属及其配偶共 5 6 6人进行空腹血糖 (FPG)、胰岛素 (Ins)、甘油三酯 (TG)和纤维蛋白原 (Fib)测定 ,并采用PCR BslN1酶解法 ,检测IRS 1基因 972密码子多态性。 结果 (1)高血压及非高血压家族的第一代直系亲属中 ,IRS 1基因Gly/Arg型频率差异不显著 (7 4 %∶5 1% ) ;(2 )多因素分析 ,排除年龄、性别影响后 ,FPG最高三分变量组 (5 35± 0 0 1)mmol/L比最低三分变量组 (4 19± 0 0 2 )mmol/L携带IRS 1基因Gly/Arg型明显增多 (OR =3 2 8)。再调整父母高血压家族史影响后结果相似。 结论 IRS 1基因可能是大庆地区部分人群血糖升高的遗传因素之一 ,但与原发性高血压无关。
Objective To investigate the relationship between insulin receptor substrate 1 (IRS 1) gene polymorphism and blood glucose in offspring of hypertensive pedigrees and non-hypertensive pedigrees. Methods A total of 566 people of 184 hypertensive pedigrees and 99 non-hypertensive pedigrees in Daqing district were enrolled in the study. FPG, Ins, triglyceride (TG) and fiber Proteins (Fib) were measured and the 972 codon of IRS 1 gene polymorphism was detected by PCR BslN1 digestion. Results (1) The frequencies of Gly / Arg in IRS1 gene were not significantly different among the first generation of immediate family members of hypertension and nonhypertension families (74%: 51%); (2) Multivariate analysis excluded the age, After sex, FPG in the highest tertile group (5 35 ± 0 0 1 mmol / L) was significantly higher than that in the lowest tertile group (4 19 ± 0 0 2) mmol / L Gly / Arg group = 3 2 8). After adjusting for the impact of family history of hypertension, the results were similar. Conclusion IRS 1 gene may be one of the hereditary factors of hyperglycemia in some people in Daqing area, but not related to essential hypertension.