论文部分内容阅读
目的:探讨动态监测CA125水平对预测卵巢上皮癌复发的临床意义。方法:选择卵巢上皮癌的患者48例,所有患者于术后及化疗后每月监测CA125水平,观察卵巢上皮癌复发和CA125水平动态变化的关系。结果:CA125<35 U/ml的患者中,CA125持续上升的患者复发率为53.85%;在临界值范围内波动的患者复发率为18.18%,两组复发率比较有统计学差异(P<0.05);CA125>35 U/ml的24例患者的复发率为66.67%;CA125水平未持续上升者复发率为33.33%,两者复发率有统计学差异(P<0.05);48例患者中,化疗第3疗程结束后CA125<35 U/ml者19例,其中有2例复发,复发率为10.53%;29例患者于化疗第3疗程结束后CA125水平≥35 U/ml,其中10例复发,复发率为34.48%,两者对比有统计学差异(P<0.05)。结论:卵巢上皮癌的复发与CA125持续上升有关,为临床预测卵巢上皮癌复发提供参考。
Objective: To investigate the clinical significance of dynamic monitoring of CA125 levels in predicting the recurrence of epithelial ovarian cancer. Methods: Forty-eight patients with ovarian cancer were selected. All patients were monitored for CA125 every month after chemotherapy and chemotherapy. The relationship between the recurrence of ovarian cancer and the dynamic changes of CA125 levels was observed. Results: The recurrence rate of patients with CA125 <35 U / ml was 53.85%, while the recurrence rate was 18.18% within the range of the threshold. There was significant difference between the two groups (P <0.05 ). The recurrence rate was 66.67% in 24 patients with CA125> 35 U / ml. The recurrence rate was 33.33% in CA125 patients without sustained increase. There were significant differences between the two groups (P <0.05) Of the 19 patients with CA125 <35 U / ml after the third course of chemotherapy, 2 patients relapsed with a recurrence rate of 10.53%. In 29 patients, the CA125 level was 35 U / mL after the third course of chemotherapy, of which 10 patients relapsed , The recurrence rate was 34.48%, the difference between the two groups was statistically significant (P <0.05). Conclusion: The recurrence of epithelial ovarian cancer is associated with the rising of CA125, which may provide a reference for the clinical prediction of ovarian cancer recurrence.