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本文报道国内合成新药N-乙基沛心达(N-EP)对兔骨骼肌肌浆网囊泡钙螯合作用和钙-ATP酶(Ca~(2+)-ATPase)活力的抑制作用以及药物与膜蛋白的比例变化对后者的影响。N-EP抑制钙转运可能与其钙拮抗作用有关。“7921”、葛根素及黄豆甙原对该酶活力无明显影响。
This article reports the inhibitory effect of N-ethyl Pentanedoxin (N-EP), a new synthetic drug, on calcium chelation and Ca-ATPase activity of sarcoplasmic reticulum in rabbit skeletal muscle. The influence of the ratio of drug to membrane protein on the latter. Inhibition of calcium transport by N-EP may be related to its calcium antagonism. “7921”, puerarin and daidzein had no significant effect on the enzyme activity.