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目的 探讨帕罗西汀对卒中后抑郁 (PSD)总体康复的疗效。方法 将 97例PSD患者随机分为帕罗西汀治疗组 (5 0例 )及对照组 (4 7例 ) ,两组均同时应用常规脑血管病治疗药物。采用汉密顿抑郁量表 (HAMD) ,汉密顿焦虑量表 (HAMA) ,临床神经功能缺损程度评分 (SSS)评定疗效和功能改善状况。结果 治疗后治疗组HAMD ,HAMA ,SSS评分较对照组低 ,差异有统计学意义。结论 帕罗西汀治疗卒中后抑郁有效 ,能改善患者情感状态及促进神经功能恢复。
Objective To investigate the effect of paroxetine on general rehabilitation of post-stroke depression (PSD). Methods Ninety-seven PSD patients were randomly divided into paroxetine treatment group (50 cases) and control group (47 cases). Both groups were treated with routine cerebrovascular disease treatment. HAMD, HAMA, and clinical neurological deficit scores (SSS) were used to evaluate the efficacy and functional improvement. Results After treatment, the scores of HAMD, HAMA and SSS in the treatment group were lower than those in the control group, the difference was statistically significant. Conclusions Paroxetine is effective in treating post-stroke depression, which can improve the emotional status of patients and promote the recovery of neurological function.