代谢紊乱是造成败血症的主要因素之一,表现为乳酸血症、血浆氨基酸增高,尤以丙氨酸及糖原异生激素浓度增高为甚。由于丙氨酸是糖原异生的重要底物,通过败血症肝脏对α-肾上腺素能刺激反应的估价,就能对糖原异生能力及氧化能力有进一步的了解。作者为此设计了灌注小鼠离体肝脏模型,使这些研究结果与周围代谢变化无关。 Metabolic disorder is one of the main factors causing sepsis, manifested as lactic acidosis, plasma amino acids increased, especially in alanine and glycogen isoforms hormone concentration is even more. Since alanine is an important substrate for gluconeogenesis, the understanding of the gluconeogenic and oxidative abilities can be further appreciated by assessing the a-adrenergic stimulatory response in the liver of sepsis. To this end, the authors designed a perfusion model of isolated liver in mice, so that the results of these studies have nothing to do with the surrounding metabolic changes.