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热休克蛋白HSP是一种广泛存在于微生物和动植物体内的一种应激蛋白.HSP在HCC的生物治疗中将发挥越来越重要的作用.HSP在生物体内起着参与加速降解和清除细胞代谢产物,维护细胞的功能和生存,协同免疫应答,调节信号传导通路,调控细胞周期,抑制凋亡以及促进微管的形成与修复等作用.大量研究显示一些HSP在肿瘤免疫中发挥作用,并有望制成基因疫苗应用于肿瘤的防治.本文综述了HSP70,HSP90,HSP47,HSP27等在肝癌的发生、发展和治疗中的进展及其在肝癌防治中的意义.
Heat shock protein HSP is a kind of stress protein widely existing in microorganism, animal and plant body, and HSP plays an increasingly important role in the biological treatment of HCC .HSP plays an important role in the organism to accelerate the degradation and clearance of cells Metabolites, maintaining cell function and survival, coordinating immune response, regulating signal transduction pathway, regulating cell cycle, inhibiting apoptosis and promoting the formation and repair of microtubules.Many studies have shown that some HSPs play a role in tumor immunity and It is expected that the gene vaccine can be used in the prevention and treatment of cancer.This review summarizes the progress of HSP70, HSP90, HSP47 and HSP27 in the occurrence, development and treatment of hepatocellular carcinoma and its significance in the prevention and treatment of liver cancer.