AIM To study the changes of endogenoustransforming growth factor β(TGFβ)and basicfibroblast growth factor(bFGF)in lung followingintestinal ischemia and reperfusion injury andtheir effects on lung injury and repair.METHODS Sixty Wistar rats were divided intofive groups,which underwent sham-operation,ischemia(45 minutes),and reperfusion(6,24and 48 hours,respectively)after ischemia(45minutes).Immunohistochemical method wasused to observe the localization and amounts ofboth growth factors.RESULTS Positive signals of both growthfactors could be found in normal lung,mainly inalveolar cells and endothelial cells of vein.Afterischemia and reperfusion insult,expressions ofboth growth factors were increased and theiramounts at 6 hours were larger than those ofnormal control or of 24 and 48 hours after insult.CONCLUSION The endogenous bFGF and TGF βexpression appears to be up-regulated in thelung following intestinal ischemia andreperfusion,suggesting that both growth factorsmay be involved in the process of lung injury andrepair. AIM To study the changes of endogenoustransforming growth factor β (TGFβ) and basic fibroblast growth factor (bFGF) in lung following intestinal ischemia and reperfusion injury and their effects on lung injury and repair. METHODS Sixty Wistar rats were divided intofive groups, which underwent sham-operation, ischemia (45 minutes), and reperfusion (6,24 and 48 hours respectively) after ischemia (45 minutes). Immunohistochemical method was used to observe the localization and amounts ofboth growth factors. inalveolar cells and endothelial cells of vein. Afterischemia and reperfusion insult, expressions ofboth growth factors were increased and theimages for 6 hours were larger than those of normal control or of 24 and 48 hours after insult. CONCLUSION The endogenous bFGF and TGF [beta] expression appears to be up -regulated in thelung following intestinal ischemia andreperfusion, suggesting that both growth factorsmay be involved in the process of lung injury and repair.