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目的评价低剂量帕罗西汀结合改进的行为疗法治疗早泄的可行性与疗效。方法将120例早泄患者随机分为3组,每组40例。试验组:口服帕罗西汀10mg/次,每晚1次,连服4周,同时进行改进后的行为疗法,为期8周;对照组Ⅰ:口服帕罗西汀20mg/次,每晚1次,连服8周;对照组Ⅱ:行为疗法,为期8周。观察各组治疗后CIPE-5积分变化、有效率、药物副反应。结果试验组治疗后CIPE-5积分及有效率均优于两对照组。药物副反应发生率明显低于对照组Ⅰ(P<0.01)。结论本组联合治疗早泄的方法临床疗效较好,副反应小,预期效果满意,值得推荐。
Objective To evaluate the feasibility and efficacy of low-dose paroxetine in combination with improved behavioral therapy for premature ejaculation. Methods 120 cases of premature ejaculation were randomly divided into 3 groups, 40 cases in each group. The experimental group: oral paroxetine 10mg / time, once a night, even for 4 weeks, while improved behavioral therapy for 8 weeks; control group Ⅰ: paroxetine oral 20mg / time, once a night, even with service 8 weeks; control group II: behavioral therapy for 8 weeks. The changes of CIPE-5 score, effective rate and side effects were observed after treatment. Results The CIPE-5 score and the effective rate in the experimental group were better than those in the two control groups. The incidence of side effects of drugs was significantly lower than that of control Ⅰ (P <0.01). Conclusion The combined treatment of premature ejaculation in this group is better in clinical efficacy, with fewer side effects and satisfactory results, which is worth recommending.