论文部分内容阅读
目的探讨斑蝥酸钠维生素B6联合PT方案对卵巢上皮性癌的近期疗效。方法选择2014年9月至2015年9月接诊的100例卵巢上皮性癌患者,按照随机数表法分为观察组和对照组,各50例。对照组给予PT方案(紫杉醇+顺铂)化疗,观察组在对照组的基础上加用斑蝥酸钠维生素B6。观察两组患者治疗前后血管内皮生长因子(VEGF)水平变化,记录治疗过程中发生的不良反应,比较治疗后临床疗效及生活质量。结果治疗后,观察组VEGF水平低于对照组[(341.56±95.49)ng/L vs(411.78±109.73)ng/L,P<0.01];不良反应总发生率低于对照组[12.0%(6/50)vs 44.0%(22/50),P<0.01];总缓解率明显高于对照组[86.0%(43/50)vs 46.0%(23/50),P<0.01];在生活质量的KPS评分中,观察组总改善率高于对照组[66.0%(33/50)vs 36.0%(18/50),P<0.01]。结论卵巢上皮性癌患者给予斑蝥酸钠维生素B6联合PT方案近期疗效优异,毒副反应少,可明显改善患者的生活质量。
Objective To investigate the short-term curative effect of sodium cantharidate vitamin B6 combined with PT on epithelial ovarian cancer. Methods A total of 100 patients with epithelial ovarian cancer who received admissions from September 2014 to September 2015 were divided into observation group and control group according to the random number table. The control group was given PT chemotherapy (paclitaxel + cisplatin). The observation group was given sodium cantharidin vitamin B6 on the basis of the control group. The changes of vascular endothelial growth factor (VEGF) levels in both groups before and after treatment were observed. The adverse reactions during the treatment were recorded. The clinical efficacy and quality of life after treatment were compared. Results After treatment, the level of VEGF in the observation group was lower than that in the control group [(341.56 ± 95.49) ng / L vs (411.78 ± 109.73) ng / L, P <0.01] / 50) vs 44.0% (22/50), P <0.01]. The overall response rate was significantly higher in the control group than in the control group [86.0% (43/50) vs 46.0% (23/50) KPS score, the total improvement rate of the observation group was higher than that of the control group [66.0% (33/50) vs 36.0% (18/50), P <0.01]. Conclusion Ovarian cancer patients with sodium cantharidin vitamin B6 combined with PT recent excellent curative effect, fewer side effects, can significantly improve the quality of life of patients.