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目的探讨滤白冷沉淀在改善肿瘤患者凝血功能异常中的应用价值。方法选取2014年1月至2016年6月大连市血液中心收治的80例肿瘤患者作为研究对象,按随机数字表法将其分为对照组和观察组,各40例。两组患者均行手术治疗,对照组患者术中根据失血量输入胶体、去白悬浮红细胞、去白新鲜冰冻血浆、晶体,术后给予常规治疗;观察组患者输入滤白冷沉淀。比较两组患者手术前后凝血指标改善情况、手术时间、出血量。结果术后8 h,观察组患者的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、D-二聚体均明显低于对照组,Fib明显高于对照组,差异均有统计学意义(均P<0.05);观察组患者术中出血量、术后24 h出血量均明显少于对照组,差异均有统计学意义(均P<0.05)。结论在肿瘤患者手术中输入滤白冷沉淀可促进止血,减少术后出血风险。
Objective To investigate the value of filtration cryogenic precipitation in improving coagulation dysfunction in patients with cancer. Methods Eighty patients with cancer who were admitted to Dalian Blood Center from January 2014 to June 2016 were selected as study subjects and divided into control group and observation group according to random number table method, 40 cases each. The two groups of patients underwent surgical treatment. Patients in the control group were given colloid on the basis of blood loss, leucocytes were white suspended, white fresh frozen plasma and crystal were given to the patients in the control group, and routine treatment was given after the operation. The improvement of coagulation index, operation time and blood loss before and after operation were compared between the two groups. Results The levels of PT, APTT, TT and D-dimer in the observation group were significantly lower than those in the control group at 8 h after operation, and the Fib was significantly higher (All P <0.05). The blood loss of operation group and the amount of hemorrhage 24 h after operation in the observation group were significantly less than those in the control group (all P <0.05) . Conclusions The filtration of cryoprecipitate during the operation of tumor patients can promote hemostasis and reduce the risk of postoperative bleeding.