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国际协作研究组最近报道,对急性心肌梗塞(简称AMI)患者发病后5小时内静脉注射β—阻滞剂噻吗心安的治疗效果。作者除观察临床变化外,尚采用累积肌酸磷酸激酶(简称CK)释放指数和连续心向量图记录分析的方法来衡量心肌损伤范围,以克服既往一些报告的局限性。 方法 首剂给予1毫克噻吗心安棕榈酸盐静脉注射,对照组则输注同量的生理盐水(安慰剂)。如无任何血流动力学不良影响或其它不良反应,则10分钟后重复给药一次。再过10分钟后,开始以每小时0.6豪克的剂量恒速静注噻吗心安,持续24小时(对照组用生理盐水),如发生持续性心动过缓(小于40次/分)或低血压(收缩压低于100毫米汞柱),则将输液速度减慢一半。若有周围组织灌注不足的临床或生化表现出现时,立即停止静注噻吗心安。静脉给药结束后,开始给予口服噻吗心安10毫克,每日二次,对照组给予
International collaborative research group recently reported on the treatment of acute myocardial infarction (AMI) patients within 5 hours after onset of β-blocker timolol intravenous treatment. In addition to observing the clinical changes, the authors used the cumulative creatine phosphokinase (CK) release index and continuous cardiac angiography to measure the extent of myocardial damage in order to overcome the limitations of some previous reports. Methods The first dose of 1 mg timolol palmitate intravenously, while the control group was infused with the same amount of saline (placebo). In the absence of any adverse effects of hemodynamic or other adverse reactions, the administration is repeated 10 minutes later. After another 10 minutes, timolol started at a constant rate of 0.6 ha for an average of 24 hours (control group with saline), with persistent bradycardia (less than 40 beats / min) or low Blood pressure (systolic blood pressure less than 100 mmHg) slowed the infusion rate by half. If there is a clinical or biochemical presentation of insufficient perfusion of the surrounding tissue, stop intravenous timolol. After intravenous administration, began to give oral timolol 10 mg twice daily, the control group given