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目的 探讨脐血血浆 (CBP)输注对恶性血液病患者化疗后细胞因子的变化和血像恢复的影响。方法 恶性血液病患者 78例化疗后治疗组于第 2、4天分别输注CBP 6个单位 ,或注射基因重组人粒细胞集落刺激因子 (rhG CSF) 15 0 μg ,对照组采用对症支持治疗 ,观察三组病例化疗后粒细胞集落刺激因子 (G CSF)和红细胞生成素 (Epo)的水平变化及骨髓和血像的恢复情况。 结果 CBP和rhG CSF治疗组外周血白细胞恢复较对照组快 (P <0 0 5 ) ,CBP输注后第 2天外周血G CSF和Epo水平达到高峰。且无输血反应及其它不良现象。 结论 恶性血液病患者化疗后输注CBP具有促进外周血白细胞恢复的功能 ,临床上具有一定的开发利用价值
Objective To investigate the effects of cord blood plasma (CBP) infusion on the changes of cytokines and the recovery of blood after chemotherapy in patients with hematologic malignancies. Methods A total of 78 patients with hematologic malignancies were treated with 6 units of CBP or 150 μg of recombinant human granulocyte colony-stimulating factor (rhG CSF) on days 2 and 4 respectively. The patients in the control group received symptomatic treatment, The changes of granulocyte colony stimulating factor (G CSF), erythropoietin (Epo) and the recovery of bone marrow and blood were observed in three groups of patients after chemotherapy. Results The recovery of peripheral blood leukocytes in CBP and rhG CSF groups was faster than that in control group (P <0.05). The levels of G CSF and Epo in peripheral blood peaked on the 2nd day after CBP infusion. And no transfusion reactions and other adverse phenomena. Conclusion The infusion of CBP after chemotherapy in patients with hematologic malignancies has the function of promoting the recovery of peripheral blood leukocytes, and has certain value in development and utilization