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感染是MDS死亡的主要原因,MDS患者易患严重感染主要与中性粒细胞减少有关。粒-巨噬细胞集落刺激因子(GM-CSF),若以60μg/m~2/d剂量,可使80％MDS患者中性粒细胞计数增加而无导致MDS转为急性粒细胞白血病(AML)的危险性,与对照组相比(给予GM-CSF3μg/kg/d)则可显著降低MDS严重感染率,但按此剂量25％MDS患者可产生副作用。另外由于GM-CSF价格昂贵,多不能坚持应用,最终导致治疗失败。为此应用小剂量
Infection is the major cause of death from MDS. The predisposition to severe infection in MDS patients is primarily associated with neutropenia. Granulocyte-macrophage colony-stimulating factor (GM-CSF) can increase the neutrophil count in 80% of MDS patients without causing MDS to change to acute myeloid leukemia (AML) at a dose of 60 μg / m 2 / Compared with the control group (given GM-CSF 3μg / kg / d) can significantly reduce the MDS serious infection rate, but according to this dose of 25% MDS patients may have side effects. In addition due to GM-CSF is expensive, more can not adhere to the application, eventually leading to treatment failure. Apply small doses for this purpose