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目的:了解冠状动脉内支架置入对组织因子(TF)和组织因子途径抑制物(TFPI)的影响;药物支架(雷帕霉素洗脱支架)和非药物支架对TF和TFPI影响是否存在差别。方法:将53例临床特征相似的急性冠状动脉综合征患者分成置入药物支架组(n=24)和非药物支架组两组(n= 29),测定置入支架前、置入后即刻、24小时后、48小时后血液中TF和TFPI的浓度,比较同组中不同时点TF和TFPI的变化以及药物支架组和非药物支架组对应时点的TF和TFPI的变化。结果:药物支架组和非药物支架组患者在置入支架后TF均显著升高;非药物支架组介入后即刻TFPI升高,以后降低至基线值以下,药物支架组也有类似趋势,但两组间对应时点TF和TFPI差别无统计学意义。结论:在现有的药物治疗基础上,置入药物支架和非药物支架对凝血和抗凝系统的影响类似,并不促进系统高凝状态的发生。
OBJECTIVE: To investigate the effects of intracoronary stent implantation on tissue factor (TF) and tissue factor pathway inhibitor (TFPI); whether TF and TFPI are affected by drug-eluting stents (rapamycin-eluting stents) and non-drug-eluting stents . Methods: Fifty-three patients with similar clinical features of acute coronary syndrome were divided into two groups (n = 29) and non-drug group (n = 29) Twenty-four hours later, the concentrations of TF and TFPI in the blood after 48 hours were compared with those of TF and TFPI at different time points in the same group, and the changes of TF and TFPI at the corresponding points of the drug-eluting and non-drug-eluting groups. Results: The TF in patients with drug-eluting stent and non-drug-eluting stent group were significantly increased after stent implantation. TFPI increased immediately after intervention in non-drug-treated stent group, and then decreased to below the baseline value. Drug-eluting stent group also had similar tendency, but both groups There was no significant difference between TF and TFPI at the corresponding time points. Conclusion: Based on the existing medical treatment, the effects of drug-eluting stent and non-drug-eluting stent on coagulation and anticoagulation system are similar, which do not promote the hypercoagulability of the system.