本文采用美沙酮与丁丙诺啡联合用药方案治疗海洛因依赖患者６０例，并与单药美沙酮组３０例，单药丁丙诺啡组３０例进行比较，结果显示联合用药组控制　断症状满意，两药过渡平衡，减药时症状反复较少，方法简便，１０ｄ左右可完成脱毒治疗．脱毒成功率为８３．３％。 In this paper, methadone and buprenorphine combination regimen in the treatment of 60 cases of heroin dependence patients with single-drug methadone group 30 patients, single-agent buprenorphine group compared with 30 patients, the results showed that the combination of drug control group off symptoms satisfactory, two Drug transition balance, reduce the symptoms repeatedly less medicine, the method is simple, 10d can be completed detoxification treatment. Virus success rate was 83.3%.