Background and Aims: Primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH) are hepatobiliary diseas-es of presumed immune-mediated origin that have been shown to overlap. The aim of this retrospective trial was to use national data to examine the characteristics and out-comes of patients hospitalized with overlapping PBC and AIH (PBC/AIH). Methods: The National Inpatient Sample was used to identify hospitalized adult patients with PBC, AIH, and PBC/AIH from 2010 to 2014 by International Clas-sification of Diseases-Ninth Edition Revision codes; patients with hepatitis B virus and hepatitis C virus infection were excluded. Primary outcomes measures were in-hospital outcomes that included mortality, respiratory failure, septic shock, length of stay, and total hospital charges. Second-ary outcomes were the clinical characteristics of PBC/AIH, including the comorbid extrahepatic autoimmune disease pattern and complications of cirrhosis. Results: A total of 3,478 patients with PBC/AIH were included in the study. PBC/AIH was associated with higher rates of Sj?gren\'s syn-drome (p<0.001; p<0.001), lower rates of Crohn\'s disease (p<0.05; p<0.05), and higher rates of cirrhosis-related complications when compared to PBC or AIH alone. There were similar rates of mortality between the PBC/AIH, PBC, and AIH groups. The PBC/AIH group had higher rates of septic shock when compared to the PBC group (p<0.05) and AIH group (p<0.05) after adjusting for possible con-founders. Conclusions: PBC/AIH is associated with a lower rate of Crohn\'s disease, a higher rate of Sj?gren\'s syn-drome, higher rates of cirrhosis-related complications, and significantly increased risk of septic shock compared to PBC and AIH individually.