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目的：观察米非司酮抗人子官内膜癌裸鼠移植瘤的作用，为临床应用提供依据。方法：将裸鼠分为米非司酮、三苯氧胺、米非司酮＋三苯氧胺、对照４组，用药并观察移植瘤生长情况，电镜观察移植瘤，测定裸鼠血清雌二醇。结果：米非司酮抗癌作用与三苯氧胺相似，二者联合作用增强。米非司酮使癌细胞坏死，内质网及线粒体肿胀，使裸鼠血清雌二醇升高。结论：米非司酮有抗子宫内膜癌作用，与三苯氧胺联合作用增强。
Objective: To observe the effect of mifepristone on human xenografts in nude mice xenografts in nude mice and provide the basis for clinical application. Methods: Nude mice were divided into four groups: mifepristone, tamoxifen, mifepristone and tamoxifen, and the control group. The growth of the transplanted tumor was observed and the transplanted tumor was observed by electron microscope. The serum estradiol was measured in nude mice. Results: The anticancer effect of mifepristone is similar to that of tamoxifen, and the combined effect of the two is enhanced. Mifepristone causes necrosis of cancer cells, swelling of the endoplasmic reticulum and mitochondria, raising serum estradiol in nude mice. Conclusion: Mifepristone has anti-endometrial cancer effect, combined with tamoxifen enhanced.