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目的观察大剂量甲泼尼松龙和小剂量甲泼尼松龙治疗重型手足口病的临床效果。方法回顾性分析80例重型手足口病患儿,其中大剂量甲泼尼松龙和小剂量甲泼尼松龙治疗组各40例,观察两组患儿的临床治疗效果。结果治疗组热退时间明显短于对照组,P<0.05,差异有统计学意义,但皮疹消退时间、神经系统受累时间、需要上呼吸机例数、死亡例数及总住院时间与对照组均差异无统计学意义,P>0.05。结论大剂量激素治疗组总体效果不优于小剂量激素治疗组,不推荐盲目使用大剂量甲泼尼松龙治疗重型手足口病。
Objective To observe the clinical effects of high-dose methylprednisolone and low-dose methylprednisolone in the treatment of HFMD. Methods A retrospective analysis of 80 cases of HFMD in children, including high-dose methylprednisolone and low-dose methylprednisolone treatment group 40 cases, the clinical efficacy of two groups were observed. Results The treatment group was significantly shorter than that of the control group, P <0.05, the difference was statistically significant, but the rash subsided time, nervous system involvement time, the need for the number of ventilator cases, the number of deaths and total hospital stay with the control group The difference was not statistically significant, P> 0.05. Conclusion The overall effect of the high-dose hormone therapy group is not superior to the low-dose hormone therapy group. It is not recommended to blindly use high-dose methylprednisolone to treat HFMD.