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神经鞘脂(sphingolipid)是生物膜脂质类的一个家族,它在调节脂质双分子层的流动性和亚结构域方面发挥着重要作用。神经酰胺(ceramide)作为神经鞘脂代谢的核心分子起着第二信使的作用,可介导细胞凋亡、分化、生长抑制等多种生物效应。细胞内神经酰胺浓度降低和恶性肿瘤抗凋亡机制之间的联系越来越密切,因此增加内源性神经酰胺浓度或外源性类似物(模拟神经酰胺活性)可以逆转肿瘤的耐药性,并为恶性肿瘤治疗提供全新方法 。
Sphingolipids, a family of biomembrane lipids, play an important role in regulating the fluidity and subdomain of lipid bilayers. Ceramide plays a second messenger role as the core molecule of sphingolipid metabolism and can mediate various biological effects such as apoptosis, differentiation and growth inhibition. Increasing the concentration of endogenous ceramides or exogenous analogues (mimicking ceramide activity) can reverse tumor drug resistance by decreasing the intracellular concentration of ceramide and increasing the link between the anti-apoptotic mechanisms of malignant tumors. And provide a new method for the treatment of malignant tumors.