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目的观察槐耳颗粒对乳腺癌术后患者外周血T淋巴细胞亚群的影响。方法经病理学检查确诊的乳腺癌术后患者90例随机分为两组,治疗组45例,应用“FEC”方案化疗(环磷酰胺0.6/m2,静脉推注,d1,表柔比星100 mg/m~2,静脉滴注,d1,5-氟尿嘧啶0.6/m~2,静脉滴注,d1,共6周期),化疗同时加用槐耳颗粒口服,20 g/次,3次/d,21 d为1个周期;对照组45例,单纯行“FEC”方案化疗,化疗前、后测定患者外周血NK细胞、CD3~+、CD4~+、CD4~+/CD8~+比值。结果治疗组治疗后外周血NK细胞、CD3~+、CD4~+、CD4~+/CD8~+比值均高于治疗前,差异有统计学意义(P<0.05);对照组治疗前、后各值差异无统计学意义(P>0.05);治疗组治疗后其值明显优于对照组,差异有统计学意义(P<0.05)。结论槐耳颗粒能提高乳腺癌术后化疗患者的免疫功能,而且无明显不良反应,值得临床进一步观察。
Objective To observe the effects of Huaier granules on T lymphocyte subsets in peripheral blood of postoperative patients with breast cancer. Methods Totally 90 patients with breast cancer diagnosed by pathological examination were randomly divided into two groups. The treatment group was treated with “FEC” chemotherapy (cyclophosphamide 0.6 / m2, intravenous bolus, d1, Star 100 mg / m ~ 2, intravenous drip, d1, 5 - fluorouracil 0.6 / m ~ 2, intravenous drip, d1, a total of 6 cycles), chemotherapy plus at the same time with Huaier particles oral, 20 g / / d and 21 d for one cycle. The control group of 45 patients were treated with “FEC” chemotherapy alone and before and after chemotherapy. The levels of NK cells, CD3 +, CD4 +, CD4 + / CD8 ~ + Ratio. Results The ratio of CD3 ~ +, CD4 ~ +, CD4 ~ + / CD8 ~ + in peripheral blood of the treatment group after treatment was significantly higher than that before treatment (P <0.05) There was no significant difference between the two groups (P> 0.05). After treatment, the treatment group was significantly better than the control group, the difference was statistically significant (P <0.05). Conclusion Huaier granules can improve the immune function of patients with postoperative chemotherapy of breast cancer, and no obvious adverse reactions, it is worth further clinical observation.