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目的:探讨鼻腔鼻窦神经内分泌癌的临床特点以及内镜下手术切除的效果。方法:回顾性分析5例鼻腔鼻窦神经内分泌癌患者(Kadish分期B期2例,C期3例)的临床资料,治疗采取鼻内镜下切除并联合放化疗(1例因术前肺转移未予手术)。结果:1例无瘤生存5年;1例术后2年局部复发予化疗1年;1例术后1年局部复发再次行鼻内镜手术+化疗;1例2年后肺部转移死亡;1例姑息化疗半年后死亡。结论:本病治疗无统一方案,经鼻内镜手术为主的综合性治疗有效可行,早期的准确诊断和综合治疗是提高生存率的关键。
Objective: To investigate the clinical features of nasal sinus neuroendocrine carcinoma and the effect of endoscopic resection. Methods: The clinical data of 5 patients with nasal sinus neuroendocrine carcinoma (2 cases in Kadish stage B and 3 cases in stage C) were retrospectively analyzed. The patients underwent endoscopic resection combined with chemoradiotherapy (one case was due to preoperative pulmonary metastasis To surgery). RESULTS: One patient survived 5 years without tumor. One patient underwent local recurrence 2 years after surgery to receive chemotherapy for 1 year. One patient underwent locally endoscopic sinus surgery plus chemotherapy one year after operation. One patient died of pulmonary metastasis two years later. One patient died of palliative chemotherapy six months later. Conclusion: The treatment of this disease without a unified program, endoscopic nasal surgery based comprehensive treatment is feasible and effective early accurate diagnosis and comprehensive treatment is to improve the survival rate of the key.