口服甾体避孕药能够引起一系列血浆蛋白浓度的改变,包括主要的高亲合力甾体结合蛋白,性激素结合球蛋白(SHBG)和皮质甾体结合球蛋白(CBG)的改变。一些研究指出雌激素类如乙炔雌二醇(EE_2)能够提高上述蛋白在血浆中的浓度,而孕激素类如 levonorgestrel 如单独使用却使血浆 SHBG 的浓度下降,如与 EE_2合用,则能够消除 EE_2使 SHBG 增高的作用。levonorgestrel 的 Oral steroid contraceptives cause changes in a range of plasma protein concentrations, including changes in major high-affinity steroid-binding proteins, sex hormone-binding globulin (SHBG), and corticosteroid-binding globulin (CBG). Some studies have shown that estrogen such as ethinyl estradiol (EE_2) can increase the concentration of these proteins in plasma, while progesterone such as levonorgestrel alone decreases the concentration of plasma SHBG, and EE_2 The SHBG increased role. levonorgestrel