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目的：评估短期泮托拉唑的使用对C13呼气试验的影响；方法选择幽门螺杆菌阳性的消化性溃疡伴出血的患者作为研究对象，以C13呼气试验作为Hp的检测方法，评估短期泮托拉唑的使用对幽门螺杆菌阳性率的影响；结果研究共纳入了110名幽门螺杆菌阳性的消化性溃疡伴出血的患者，其中十二指肠溃疡76名，胃溃疡18名，复合性溃疡16名，泮托拉唑使用1天～3天后，幽门螺杆菌的阳性降低至54.2%，延长泮托拉唑使用时间至4天～6天，幽门螺杆菌的阳性率逐步升高至95.1%。结论研究表明，在消化性溃疡伴出血患者，泮托拉唑短期使用并不会降低幽门螺杆菌的阳性率。“,”Objective Evaluation the effectofshort term use of pantoprazolein the accuracy of13C breath test;Methods This study choose the H pylori positive peptic ulcer with hemorrhage as the research object,use 13C breath test as the detective method of H pylori after treatment,assess the effect ofshort-termpantoprazole use forthe positive rateof Helicobacter pylori;Results The studyincluded 110Helicobacter pylori positive pepticulcer patients with hemorrhage, including 76 duodenal ulcer,18 gastric ulcer and 16 compound ulcer.After 1 to 3days’ treatment,the positive rate reduced to 54.2%,extending the use time to 4 to 6 days,The positive rateof Helicobacter pyloriincreased to 95.1%.Conclusion The study show that,in peptic ulcer patients with bleeding,short-term use Pantoprazoledoes not reducethe positive rateof Helicobacter pylori.