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目的探讨柱状细胞亚型甲状腺乳头状癌(CCV-PTC)的临床病理特征和诊断要点。方法分析1例CCV-PTC临床资料,观察其组织学形态及免疫表型特征,并复习相关文献。结果患者女性,54岁,发现右颈部肿块25年,组织学显示:肿瘤有一层较厚的包膜,肿瘤细胞柱状、假复层排列,形成乳头状、滤泡状、小梁状、复杂的腺管状和实片状。免疫表型:TTF1、p16(+),TG、Cyclin D1、p53弱(+),CK19、ER、PR、CDX2、Villin、HMBE-1均(-)。结论 CCV-PTC是一种少见的更具侵袭性甲状腺乳头状癌亚型,依据临床和病理组织学特点,结合免疫组化染色可以明确诊断。
Objective To investigate the clinicopathological features and diagnosis of thyroid papillary thyroid carcinoma (CCV-PTC). Methods A case of CCV-PTC clinical data was analyzed, the histological features and immunophenotypes were observed, and the related literature was reviewed. RESULTS: A 54-year-old female patient with a 25-year history of right-neck mass showed a thicker envelope of tumor with columnar and pseudostratified tumor cells that formed a papillary, follicular, trabecular, complex The glandular tube and the real sheet. Immunophenotype: TTF1, p16 (+), TG, Cyclin D1, p53 weak (+), CK19, ER, PR, CDX2, Villin, HMBE-1. Conclusion CCV-PTC is a rare and more invasive subtype of papillary thyroid carcinoma. Based on the clinical and histopathological features, combined with immunohistochemical staining can confirm the diagnosis.