目的 :p16蛋白和 NDPK/ nm2 3在不同类型、不同分期的卵巢上皮性肿瘤的表达情况。方法 :采用 S- P法免疫组化染色观察 p16蛋白和 NDPK/ nm2 3在 37例卵巢良性肿瘤、33例卵巢交界性肿瘤和 6 9例卵巢上皮癌的表达情况。结果 :在卵巢癌中 ,p16蛋白表达阳性率降低 (5 0 .7% ,P <0 .0 1) ;NDPK/ nm2 3表达阳性率增高 (73.9% ,P <0 .0 5 )。p16蛋白表达与组织学类型无关 (P >0 .0 5 ) ;而 NDPK/ nm2 3在粘液性癌表达阳性率 (5 4.5 % )与浆液性癌 (82 .2 % )和子宫内膜样癌 (83.3% )比较 ,差异显著 (P <0 .0 5 )。 p16蛋白和 NDPK/ nm2 3在不同分化程度卵巢癌中的表达无显著差异。两基因产物在 ～ 期癌表达阳性率 (p16蛋白 :6 8.0 % ;NDPK/ nm2 3:88.0 % )均高于 ～ 期癌 (p16蛋白 :38.7% ;NDPK/ nm2 3:6 4.5 % ) (P <0 .0 5 )。结论 :抑癌基因 CDKN2的基因产物 p16蛋白表达缺失在卵巢癌的发生和发展中可能都起重要作用 ;而 nm2 3基因的过度表达对卵巢癌的发生起重要作用 ,而对其发展可能不起主要作用 PURPOSE: The expression of p16 protein and NDPK / nm23 in different types and stages of epithelial ovarian cancer. Methods: The expressions of p16 protein and NDPK / nm23 in 37 cases of ovarian benign tumor, 33 cases of ovarian borderline tumor and 69 cases of epithelial ovarian cancer were observed by S-P immunohistochemical staining. Results: The positive rate of p16 protein expression in ovarian cancer was decreased (50.7%, P <0.01). The positive rate of NDPK / nm23 expression was increased (73.9%, P <0.05). The positive rate of NDPK / nm23 in mucinous carcinoma (4.55%) and serous carcinoma (82.2%) and endometrioid carcinoma were not correlated with histological types (P> 0.05) (83.3%), the difference was significant (P <0.05). There was no significant difference in the expression of p16 protein and NDPK / nm23 in ovarian cancer with different degrees of differentiation. The positive rates of p16 protein and p16 protein in the cancer stage were higher than those in the cancer stage (P16 protein: 38.7%; NDPK / nm23: 4.5%) (P <0 .0 5). CONCLUSION: The loss of p16 protein, a product of tumor suppressor gene CDKN2, may play an important role in the occurrence and development of ovarian cancer. Overexpression of nm23 gene may play an important role in the development of ovarian cancer, main effect