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目的:研究黄芪生脉饮联合西医综合治疗小儿反复呼吸道感染的(RRTI)效果及免疫状况并进行分析。方法:选取2012年3月—2015年4月期间,医院收治的120例RRTI患者,采用随机数表法,将120例患者平均分为研究组和对照组,每个组各60例。发作期针对两组患者均采取常规西医治疗,缓解期针对对照组采取转移因子口服液治疗,10 m L/次,每天1次,口服;研究组患者采取黄芪生脉饮治疗,10 m L/次,2次/d,口服。两组患者治疗疗程都为8周,并且对所有患者行6个月的随访。观察记录患者的肺脾气虚证积分,检测治疗前后患者的T细胞亚群以及免疫球蛋白。结果:经治疗后研究组的总有效率高达98.33%,明显的高于对照组的有效率68.33%,并且差异具有统计学意义(χ~2=19.440 0,P=0.000 0);研究组患者治疗后IgG与IgA明显高于对照组,且差异具有统计学意义(P<0.05);研究组患者CD_3~+、CD_4~+、CD_8~+以及CD_4~+/CD_8~+改善程度明显地优于对照组,差异具有统计学意义(P<0.05);研究组患者治疗后各症状积分与肺脾气虚证总积分都显著低于对照组,差异具有统计学意义(P<0.05)。结论:发作期两组患者均采取常规西药治疗,缓解期采取黄芪生脉饮治疗,可显著地改善患儿体质,提高治疗有效率,减轻患儿的临床症状,减少痛疼,值得在临床上推广应用。
Objective: To study the effect and immune status of Astragalus Shengmai Decoction combined with western medicine in the treatment of recurrent respiratory tract infections in children. Methods: From March 2012 to April 2015, 120 RRTI patients admitted to the hospital were randomly divided into study group and control group, with 60 cases in each group. The patients in the attack group were treated with routine western medicine in the two groups, and the control group were treated with the transfer factor oral solution in the remission period, 10 m L / time, once daily, orally. The patients in the study group were treated with Astragalus Sheng Mai Yin, 10 m L / Times, 2 times / d, orally. Both groups were treated for 8 weeks, and all patients were followed up for 6 months. Observe and record the patient’s spleen-qi Deficiency score, test patients before and after treatment of T-cell subsets and immunoglobulin. Results: After treatment, the total effective rate of the study group was 98.33%, significantly higher than that of the control group (68.33%), and the difference was statistically significant (χ ~ 2 = 19.440 0, P = 0.000 0) The levels of IgG and IgA in the treatment group were significantly higher than those in the control group (P <0.05). The improvement of CD_3 ~ +, CD_4 ~ +, CD_8 ~ + and CD_4 ~ + / CD_8 + (P <0.05). The scores of each symptom score and the total score of lung, spleen and Qi deficiency syndrome in the study group were significantly lower than those in the control group, the difference was statistically significant (P <0.05). Conclusion: The two groups of patients were treated by conventional western medicine in the attack stage. Astragalus Shengmai Yin was taken during the remission stage, which could significantly improve the physique, improve the treatment efficiency, alleviate the clinical symptoms and reduce the pain, Promote the application.