目的　评价丙戊酸钠常规剂型和缓释片治疗癫疒间 的临床疗效、血药质量浓度和药物不良反应。方法　 3 3例癫疒间 病人服用丙戊酸钠常规剂型治疗 6月以上 ,换用同等剂量丙戊酸钠缓释片治疗 4周 ,分别于服药 12h和 2 4h清晨服药前测量两种不同剂型丙戊酸质量浓度 ,观察临床疗效和药物不良反应。结果　丙戊酸钠缓释片谷质量浓度明显高于常规剂型 ;服用缓释片癫疒间 控制率 76%明显高于常规剂型 45 % (P <0 0 5 ) ,5例发作显著减少。常规剂型和缓释片治疗中共有 5例出现药物不良反应 ,均与血药质量浓度水平升高和个体对药物耐受量有关。结论　丙戊酸钠缓释片持久平稳升高血药质量浓度水平 ,减少服药间期波动 ,是一种更有效、服用更方便抗癫疒间 药物剂型 Objective To evaluate the clinical efficacy of conventional sodium valproate and sustained-release tablets in the treatment of epilepsy, the plasma concentration and drug adverse reactions. Methods 3 patients with epilepsy patients taking sodium valproate conventional dosage form for more than 6 months, with the same dose of sodium valproate sustained-release tablets for 4 weeks, respectively, at 12h and 24h before taking medication in the morning before taking two different dosage forms Valproate mass concentration, observe the clinical efficacy and adverse drug reactions. Results The sodium valproate sustained-release tablets had a significantly higher cereal concentration than the conventional formulations. The controlled rate of taking epilepsy was 76% higher than that of the conventional dosage form (P <0.05), and the incidence of 5 cases was significantly reduced. There were 5 cases of adverse drug reactions in routine dosage form and sustained-release tablets, both of which were related to the increase of plasma concentration level and individual tolerance to drug. Conclusion Sodium valproate sustained-release tablets sustained and steady rise in plasma concentration levels, reduce medication interval fluctuations, is a more effective, taking more convenient anti-epileptic drug dosage forms