目的研究灵芝海参提取物对高脂血症人群血脂的影响。方法选择符合高脂血症患者120例,随机分为治疗组和对照组各60例,治疗组口服灵芝海参提取物,对照组口服安慰剂,连服45 d,试食前后观察安全性和功效性指标。结果试食后治疗组TC、TG水平明显下降,下降率分别为11.76±6.12%、16.63±7.62%,自身前后比较及与对照组比较差异均有统计学意义(P<0.05);HDL-C改善程度自身前后比较及与对照组比较均无统计学差异(P>0.05)。结论灵芝海参提取物具有辅助降低高脂血症人群血清总胆固醇和甘油三酯的作用,其安全性为I级。 Objective To study the effects of Ganoderma lucidum sea cucumber extract on blood lipids in hyperlipidemic patients. Methods A total of 120 patients with hyperlipidemia were randomly divided into treatment group (60 cases) and control group (60 cases). The treatment group was orally administered Ganoderma lucidum sea cucumber extract. The control group was given oral placebo for 45 days. The safety and efficacy Sexual indicators. Results After treatment, the levels of TC and TG in the treatment group decreased significantly (P <0.05), and the rates of decline were 11.76 ± 6.12% and 16.63 ± 7.62%, respectively (P <0.05). HDL-C There was no significant difference in the degree of improvement between before and after treatment and the control group (P> 0.05). Conclusion Ganoderma lucidum sea cucumber extract has the effect of reducing serum total cholesterol and triglyceride in hyperlipidemic patients, and its safety is Grade I.