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选择本院在1998年1月～2008年7月内分泌科门诊和病房收治的既往有Graves病,服用抗甲状腺药物1年以上,停药10年的,以甲减就诊的病人16例。分析16例患者的临床资料,包括症状、体症、内分泌激素水平和治疗情况。研究其原因有:(1)自身免疫性甲状腺疾病的自然病程;(2)甲状腺细胞的凋亡,凋亡和抗凋亡分子在Graves患者中的不同作用,表现为甲状腺细胞的增生和亢进,与此相反,HT则表现为低下;(3)甲状腺素受体抗体(TRAb)中的阻断成分TSBAb可能是Graves病(GD)患者发生甲减的原因,TRAb不同组分的优势变化会引起甲状腺功能的波动。
Select our hospital in January 1998 ~ July 2008 Department of Endocrinology and Ward admitted to the past with Graves disease, taking anti-thyroid drugs for more than 1 year, withdrawal of 10 years, 16 cases of hypothyroidism treatment. Clinical data of 16 patients were analyzed, including symptoms, physical signs, levels of endocrine hormones and treatment. The reasons are as follows: (1) the natural course of autoimmune thyroid disease; (2) the different roles of thyroid apoptosis, apoptosis and anti-apoptotic molecules in Graves patients, which are manifested as hyperplasia and hyperthyroidism of thyroid cells, Conversely, HT is subsided; (3) TSBAb, a blocking component in thyroid hormone receptor antibody (TRAb), may be the cause of hypothyroidism in patients with Graves’ disease (GD), and changes in the predominance of different components of TRAb may cause Thyroid function fluctuations.