四、抗性的遗传与生化机制活细胞对外来毒物的敏感程度主要取决于质膜对毒物的透性,激活剂、非激活剂和颉抗剂的存在,胞内作用位点的性质及其与毒物的亲和力,相应的替换代谢支路的存在等。这些性质均受遗传控制。根据学者们研究,作用于细胞表面、细胞膜,酶和蛋白质的药剂不易产生抗性,而影响胞核的药剂容 Fourth, the genetic and biochemical mechanism of resistance The sensitivity of living cells to foreign toxins mainly depends on the permeability of the plasma membrane to the poison, the presence of activators, non-activators and antagonists, the nature of intracellular sites and their Affinity with poison, the corresponding replacement of the existence of the metabolic branch and so on. These properties are all genetically controlled. According to scholars study, acting on the cell surface, cell membrane, enzymes and proteins of the drug is not easy to produce resistance, and affect the nucleus of the drug content