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Autoimmune mechanisms are likely involved in the pathogenesis of idiopathic dilated cardiomyopathy (IDC)and components of MHC may serve as markers for the propensity to develop immune-mediated myocardialdamage.This study was conducted to investigate the possible association between HLA-DQA1,-DQB1 allelesand IDC in Han population from northern China by using PCR-based sequence-specific primer (PCR-SSP)technique for HLA genotyping.Among 68 unrelated IDC patients,4 probands of IDC pedigrees and 100healthy controls,we found that the alleles of HLA-DQA1*0501 and HLA-DQB1*0303 conferred susceptibilityto IDC while HLA-DQA1*0201 and HLA-DQB1*0502,*0504 alleles were in negative association with IDC.Theserine at position 57 (SER~(57)) in the exon of HLA-DQB1*0502 and *0504 was confirmed in our experiment as amarker for resistance to IDC.The results suggest that HLA-DQ polymorphism may be involved in thepathogenesis of IDC.Cellular & Molecular Immunology.2004;1 (4):311-314.
Autoimmune mechanisms are likely involved in the pathogenesis of idiopathic dilated cardiomyopathy (IDC) and components of MHC may serve as markers for the propensity to develop immune-mediated myocardial imaging. This study was conducted to investigate the possible association between HLA-DQA1, -DQB1 allelesand IDC in Han population from northern China by using PCR-based sequence-specific primer (PCR-SSP) technique for HLA genotyping. Among 68 unrelated IDC patients, 4 probands of IDC pedigrees and 100 heathy controls, we found that the alleles of HLA-DQAl * 0501 and HLA-DQB1 * 0303 conferred susceptibility to IDC while HLA-DQA1 * 0201 and HLA-DQB1 * 0502, * 0504 alleles were in negative association with IDC.Theserine at position 57 (SER ~ (57)) in the exon of HLA -DQB1 * 0502 and * 0504 was confirmed in our experiment as a marker for resistance to IDC. The results suggest that HLA-DQ polymorphism may be involved in the pathogenesis of IDC. Cellular & Molecular Immunology. 2004; 1 (4): 311-314 .