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目的探讨生酮饮食(KD)对兔心肌缺血再灌注损伤影响。方法分别给予雄性兔正常饮食(normal diet,ND)和KD6周后,结扎免冠状动脉左前降支30 min后,恢复再灌注180 min,通过观察心电图、心肌酶学和心肌梗死范围指标,评价KD对兔心肌缺血再灌注损伤的保护作用。结果 A组(ND+假手术组)乳酸脱氢酸、肌酸激酶活力未升高,心电图无变化,心肌无梗死。B组(ND+缺血再灌注组)变化明显。C组(KD+缺血再灌注组)较B组轻。结论用KD干预后,兔心肌缺血再灌注损伤减轻。
Objective To investigate the effect of ketogenic diet (KD) on myocardial ischemia-reperfusion injury in rabbits. Methods After the normal diet (ND) and the KD of 6 weeks, the left anterior descending coronary artery was ligated for 30 min and then reperfused for 180 min. The indexes of electrocardiogram, myocardial enzymology and myocardial infarction were used to evaluate the KD Protective effect of myocardial ischemia-reperfusion injury in rabbits. Results In group A (ND + sham operation group), the activity of lactate dehydrogenase and creatine kinase did not increase, the electrocardiogram did not change and myocardial infarction did not occur. Group B (ND + ischemia-reperfusion group) changes significantly. Group C (KD + ischemia-reperfusion group) than the B group. Conclusions After KD intervention, myocardial ischemia-reperfusion injury is alleviated.